SLU-PP-332

SLU-PP-332 — ERR Pan-Agonist / Exercise Mimetic
For Research Use Only — Not for Human or Animal Consumption
SLU-PP-332 is a synthetic compound developed at Saint Louis University that functions as a pan-agonist of estrogen-related receptors (ERRs), specifically targeting ERRα, ERRβ, and ERRγ with highest potency at ERRα. Estrogen-related receptors are nuclear transcription factors that regulate gene networks governing oxidative metabolism, mitochondrial biogenesis, and energy homeostasis. Because these pathways are also activated by endurance exercise, SLU-PP-332 is classified as an exercise mimetic — a compound that reproduces cellular adaptations associated with aerobic physical activity through pharmacological means. apextides
The molecular mechanism centers on ERRα’s control of the DDIT4 pathway. Research published in ACS Chemical Biology (2022) demonstrated that SLU-PP-332 induces DDIT4 expression specifically through ERRα activation, recapitulating a key genetic response observed after short bouts of aerobic exercise in humans. apextides At the receptor level, SLU-PP-332 binds to the ligand-binding domain of ERRα, promoting receptor activation and interaction with transcriptional coactivators such as PGC-1α apextides — a central regulator of mitochondrial biogenesis and oxidative capacity. Downstream targets include genes encoding proteins involved in fatty acid oxidation, oxidative phosphorylation, and mitochondrial structural remodeling in skeletal muscle cells.
In murine studies, acute administration activated an aerobic-exercise transcriptional program, increased mitochondrial respiration and fatty acid oxidation in skeletal muscle, and improved endurance capacity and cardiometabolic phenotypes. All evidence to date is preclinical — no human trials have been conducted. Infinitypeptide Its mechanism works via gene transcription and receptor activation, not pituitary feedback loops or hormonal axes, and no liver, kidney, or cardiac toxicity has been reported in preclinical trials. PeptideSciences Researchers investigating mitochondrial dysfunction, metabolic signaling, or transcriptional regulation of exercise-responsive gene networks will find SLU-PP-332 a well-characterized and reproducible experimental probe.